I've used high performance computing techniques with Python (and C++) for 10 years to solve a large set of interesting scientific problems, often involving Artificial Intelligence. Along the way I've learned some good approaches to tackling CPU-bound problems with a variety of libraries. I also teach Python programming and lecture on H.P.C. and Artificial Intelligence.
Blog: http://ianozsvald.com/
Twitter: http://twitter.com/ianozsvald